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The course of coronavirus disease-2019 (COVID-19) differs from person to person. The relationship between the genetic variations of the host and the course of COVID-19 has been a matter of interest. In this study, we investigated whether Angiotensin-Converting Enzyme ( ACE)  ID, Methylenetetrahydrofolate Reductase ( MTHFR)  C677T, and Macrophage Migration Inhibitory Factor ( MIF) -173GC variants are risk factors for the clinical course of COVID-19 disease in Turkish patients. One hundred COVID-19 patients were included in the study. The diagnosis of COVID-19 was made using Reverse Transcription Polymerase Chain Reaction (RT-PCR) and Chest Computed Tomography (CT). The patients were evaluated in 3 groups: intensive care, service, and outpatient treatment.  ACE  ID,  MTHFR  C677T, and  MIF -173GC variants were genotyped by PCR-Restriction Fragment Length Polymorphism (RFLP) methods. When the genotype distribution between the groups was examined, it was found that the frequency of the  ACE  DD genotype and the D allele was higher in the intensive care group compared to the hospitalized and outpatient groups.  MTHFR  C677T CT genotype T allele and  MIF-173 GC, CC genotype C allele were more prevalent in the intensive care group compared to other groups. Patients with PCR-positive results had a higher  MTHFR  C677T C/C genotype and C allele. In CT-positive patients, the  MTHFR  C677T CT genotype and the  MIF -173GC, G allele were more common. It is predicted that genetic predisposition may contribute to COVID-19 morbidity and mortality. Our results show that  ACE  ID,  MTHFR  C677T, and  MIF -173GC variants affect the course of COVID-19 disease in the Turkish population.

Association of ACE ID, MTHFR C677T, and MIF -173GC variants with the clinical course of COVID-19 patients