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Osteoarthritis (OA) is a complex disorder characterized by degenerative articular cartilage in which inflammatory mechanisms play a major role in the pathogenesis. Interleukin-6 (IL6), a multifunctional cytokine, can trigger osteoclast differentiation and bone resorption. Our purpose in this study was to evaluate the association of  IL-6  −174 G/C (rs1800795) and −572 G/C (rs1800796) variants with the susceptibility to OA. One hundred fifty OA patients and 150 healthy individuals were enrolled in the study. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was used for genotyping the  IL-6  gene variants. The results of analyses were evaluated for statistical significance. The pain intensity was assessed using the Visual Analogue Scale (VAS). There was a statistically significant difference in the genotype and allele frequencies of the  IL-6  −174 G/C variant between patients with OA and control groups ( p = 0.001, p = 0.002,  respectively).  IL-6  −174 G/C GG genotype and G allele were more prevalent in patients with OA. We found that the  IL-6  –572 G/C variant was not different between patients and controls in either genotype distribution and allele frequency.  IL-6  174 G/C and −572 G/C loci GG-GG combined genotype was significantly higher in OA patients ( p = 0.00 ). Our study suggests that there was a strong association between the  IL-6  −174 G/C variant and OA in the Turkish population. Further studies on populations of different ethnic background are necessary to prove the association of  IL-6  variants with OA.

Effect of IL-6 -174G/C and -572G/C variants on susceptibility to osteoarthritis in Turkish population