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Compare the relative efficacy of Desyncra TM  and Cognitive Behavioural Therapy (CBT). Sixty-one participants were randomly assigned to receive either Desyncra TM  ( n  = 29) or CBT ( n  = 32). Randomisation included stratification regarding current hearing aid (HA) use. Depending on group assignment, participants attended approximately 7–12 visits. Tinnitus distress was measured using the Tinnitus Questionnaire (TQ). Mean TQ scores decreased post-baseline from 5–15 points across treatment arms and strata. Model-based findings for the no-HA stratum showed a difference of −2.0 TQ points favouring Desyncra at 24-weeks, with a 90% posterior interval varying from −5.4 points favouring Desyncra to 0.8 TQ points favouring CBT. For the HA stratum, results show a difference of −1.0 TQ points favouring Desyncra, with a 90% posterior interval ranging from −4.7 points favouring Desyncra to 2.9 points favouring CBT. The difference between Desyncra and CBT on average showed greater improvement with Desyncra in the no-HA stratum by about 2 TQ points. To the extent that the study sample represents a clinical population and recognising the assumptions in the design and analysis, these results suggest Desyncra is just as effective or more so than CBT in reducing tinnitus distress.

Randomised controlled trial of interventions for bothersome tinnitus: Desyncra TM versus cognitive behavioural therapy