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Extended-spectrum beta-lactamases producing Enterobacteriaceae (ESBL-PE) represent a major problem in wound infections. Here, we investigated the prevalence and molecular characterization of ESBL-PE associated with wound infections in North Lebanon. A total of 103 non-duplicated  E. coli  and  K. pneumoniae  strains isolated from 103 patients with wound infections, were collected from seven hospitals in North Lebanon. ESBL-producing isolates were detected using a double-disk synergy test. In addition, multiplex polymerase chain reaction (PCR) was used for the molecular detection of ESBLs genes. E. coli  was the predominant bacteria (77.6%), followed by  K. pneumoniae  (22.3%). The overall prevalence of ESBL-PE was 49%, with a significantly higher rate among females and elderly patients.  K. pneumoniae  was the common MDR and ESBL-producer bacteria (86.95% and 52.17%) compared to  E. coli  (77.5% and 47.5%). Most of the isolated ESBL producers harbored multiple resistant genes (88%), where bla CTX-M  was the most predominant gene (92%), followed by bla TEM  (86%), bla SHV  (64%), and bla OXA  genes (28%). This is the first data on the ESBL-PE prevalence associated with wound infections in Lebanon, showing the emergence of multidrug-resistant ESBL-PE, the dominance of multiple gene producers, and the widespread dissemination of bla CTX-M  and bla TEM  genes.

High frequency and molecular characterization of ESBL-producing Enterobacteriaceae isolated from wound infections in North Lebanon