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Candida auris  is included in the fungal infection category ‘critical’ by WHO because of associated high drug tolerance and spread at an alarming rate which if remains untouched may result in serious outbreaks. Since its discovery in 2009, several assiduous efforts by mycologists across the world have deciphered its biology including growth physiology, drug tolerance, biofilm formation, etc. The differential response of various strains from different clades poses a hurdle in drawing a final conclusion. This review provides brief insights into the understanding of  C. auris  biofilm. It includes information on various models developed to understand the biofilms and conservation of different signaling pathways. Significant development has been made in the recent past with the generation of relevant in vivo and ex vivo models. The role of signaling pathways in the development of biofilm is largely unknown. The selection of an appropriate model system is a must for the accuracy and reproducibility of results. The conservation of major signaling pathways in  C. auris  with respect to  C. albicans  and  S. cerevisiae  highlights that initial inputs acquired from orthologs will be valuable in getting insights into the mechanism of biofilm formation and associated pathogenesis.

Candida auris biofilm: a review on model to mechanism conservation