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Candida  species have been regarded as global health threats due to their ability to cause invasive infections. It is challenging to treat  Candida  bloodstream infections, which are associated with high mortality levels. Monotherapy with antifungals is sometimes not effective against severe  Candida  infections, and combination therapy is needed in clinical practice. This review was undertaken based on data from a PubMed search for English language reports published before March 2021 by using the terms ‘caspofungin,’ ‘ Candida  species,’ ‘combination therapy,’ ‘antifungal effect,’ and ‘novel antifungal agent.’ Combination therapy is an empirical strategy for treating refractory  Candida  infections. Caspofungin has been recommended to treat candidaemia. Caspofungin in combination therapy has some applications, while the efficacy of combination therapy in the treatment of refractory  Candida  infections needs more study, such as randomized controlled trials. In addition, novel compounds or drugs with potential antifungal activities have been examined, and some of them exhibit synergistic interactions with caspofungin. Thus, the antifungal activity of caspofungin in combination with antifungals or non-antifungals against  Candida  species  in vitro  and in clinical therapy is summarized.

The antifungal activity of caspofungin in combination with antifungals or non-antifungals against Candida species in vitro and in clinical therapy