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Antidiabetic activity of methanolic extract, petroleum ether, ethyl acetate and  n -butanol fractions of  Ipomoea cairica  (L.) Sweet leaves was performed  in-vitro  using  α -glucosidase and  α -amylase inhibition methods. Phytochemical study of the ethyl acetate fraction which possessed the highest antidiabetic activity led to isolation of five flavonoids for the first time from this plant, including two rare flavonoid sulphates, ombuin-3-sulphate [ 1 ] and rhamnetin-3-sulphate [ 2 ] and three flavonoid glycosides, kaempferol 7- O - α -L-rhamnopyranoside [ 3 ], kaempferol 3,7-di- O - α -L-rhamnopyranoside [ 4 ] and quercetin 3- O - α -L-arabinopyranoside [ 5 ]. The  1 H and  13 C NMR of  1  and  13 C NMR of  2 , were reported here for the first time. Compounds [ 1 - 4 ] showed a concentration-dependent  in-vitro  inhibitory activity against  α- glucosidase and  α- amylase. Furthermore,  in-silico  study predicted that compounds ( 1 - 5 ) showed good interactions with  α- glucosidase,  α- amylase, and protein tyrosine phosphatase 1b.

natural product research

Antidiabetic activity of  Ipomoea cairica  (L.) Sweet leaves:  in-vitro  and  in-silico  antidiabetic potential of isolated flavonoid glycosides and sulphated flavonoids