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The search for new bioactive substances with anticancer activity and the understanding of their mechanisms of action are high priorities in the research effort toward more effective cancer treatments. In this article, we analyzed, for the first time, the chemical composition of the essential oil (EO) hydrodistilled from the aerial parts of  Vicia ochroleuca  Ten. (Leguminosae) by GC–MS. A total of sixteen compounds representing 82.2% of the total composition were identified. The major compounds were phytone (20.11%), hexadecanoic acid (10.23%), 1-octen-3-ol (9.84%), and 10- epi -α-cadinol (7.13%). Additionally, using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) method, the EO was tested  in vitro  against a panel of human cancer cells, including breast (MDA-MB 231), colon (HCT116), melanoma (A375), and glioblastoma (T98G), with corresponding IC 50  values of 23.07, 47.05, 51.64, and 64.07 μg/mL, respectively. The results demonstrate cytotoxic activity and suggest that  V. ochroleuca  EO could be regarded as a natural bioactive source.

Chemical composition and anticancer activity of the essential oil from Vicia ochroleuca Ten., quite rare plant in Kabylia (Algeria)