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Three new compounds ( 1 – 3 ), including two bisamide derivatives ( 1  and  2 ) and a lignin ( 3 ), along with 15 known compounds were isolated from  Aglaia odorata.  Compound  2  was a pair of enantiomers and successfully resolved into the anticipated enantiomers. Their structures were elucidated by extensive spectroscopic analysis, electronic circular dichroism (ECD) calculations, and X-ray crystallography. Three compounds showed excellent inhibitory activities on  α -glucosidase with IC 50  values ranging from 54.48 to 240.88  μ M, better than that of the positive control (acarbose, IC 50  = 590.94  μ M). Moreover, compounds  3 ,  13 , and  15  presented moderate inhibitory activities against butyrylcholinesterase. Compound  17  exhibited potent PTP1B inhibitory activity with an IC 50  value of 179.45 μM. Representative active compounds were performed for the molecular docking study. Herein, we described the isolation, structure elucidation, the inhibitory effects on three enzymes, and molecular docking of the isolates from the title plant.

Phenolic and bisamide derivatives from Aglaia odorata and their biological activities