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In this study, twenty-four organic extracts from six marine sponge species, collected at shallows of Yucatan, Mexico, were evaluated against  Giardia lamblia  trophozoites and Vero cells. The dichloromethane and hexane extracts of  Haliclona tubifera  exhibited the highest antigiardiasic activity (IC 50  = 1.00 and 2.11 µg/mL, respectively), as well as high selectivity (SI = 41.8 and &gt; 47.4, respectively), while ethyl acetate and methanol extracts of  Cinachyrella alloclada , and methanol extract of  Suberites aurantiaca  showed moderate activity. Contrastingly, the extracts of  Halichondria magniculosa  and  Oceanapia nodosa  were considered non actives. Consequently, the dichloromethane extract of  H. tubifera  were subject to an exploratory chemical study, isolating cholesterol, two benzaldehyde derivatives, three benzoic acid derivatives, cytosine, and thymine.

natural product research

Effect of extracts from several sponges of Yucatan Coast on  Giardia lamblia  and preliminary chemical investigation of the bioactive extract of  Haliclona  ( Reinera )  tubifera