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Thirteen sesquiterpene lactone derivatives were designed and synthesised using the sesquiterpene lactone epimers  TBA  and  TBB  as the parent molecules, isolated from  Sphagneticola trilobata . Their structures were elucidated by extensive spectroscopic studies and chemical evidence. Furthermore, the structures of  1a ,  4b  and  5a  were confirmed by X-ray single-crystal diffraction analyses. All of the compounds were further examined for their  in vitro  antiproliferative activity against human cancer cell lines HeLa and MCF-7. Unfortunately, the activity of all derivatives were weaker than that of the parental compounds.

Structure modification and anti-tumor activity evaluation on sesquiterpene lactones TBA and TBB from Sphagneticola trilobata