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Resveratrol is a polyphenolic compound whose antitumor activity has been demonstrated in several types of cancer. However, there are few studies on its molecular mechanisms of action in bladder cancer. Therefore, we aimed to evaluate resveratrol activity in bladder tumour cells with different  TP53  gene status. Cytotoxicity, cell proliferation, reactive oxygen species (ROS) production, cell migration, mutagenicity, and  CDH1 ,  CTNNBIP1 ,  HAT1 ,  HDAC1 ,  MYC , and  SMAD4  gene expression were evaluated. An increase in ROS after resveratrol treatment was accompanied by reduced cell viability and proliferation in all cell lines. In  TP53  wild-type cells, the inhibition of cell migration was accompanied by  CDH1  and  SMAD4  modulation. In  TP53  mutated cells, cell migration inhibition with  CDH1  and  CTNNB1P1  upregulation was observed. In conclusion, resveratrol has antiproliferative effect in bladder tumour cells and its mechanism of action occurred through ROS production, interference with cell cycle, and inhibition of cell migration, independent of  TP53  status.

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Resveratrol induces the production of reactive oxygen species, interferes with the cell cycle, and inhibits the cell migration of bladder tumour cells with different TP53 status