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Jeffreycia zeylanica  (L.) H. Rob., S. C. Keeley &amp; Skvarla is used for the treatment of wounds in indigenous medicine practiced in Sri Lanka. The scratch wound assay (SWA) guided fractionation of hexanes extract of  J. zeylanica  led to the isolation of ethuliacoumarin ( 1 ), stigmasterol ( 2 ),  β -amyrin ( 3 ) and lupeol ( 4 ) and a non-resolved triterpene alcohol mixture HF 5D1 , all of which showed enhanced cell migration. The mixture HF 5D1  contained glut-5-en-3 β -ol ( 5 ) and friedelin-3 β -ol ( 6 ). The identities of compounds  1 – 6  were established by the analysis of spectroscopic data and comparison of them with those reported. The compounds  1 – 4  and the non-resolved triterpene alcohol mixture, HF 5D1  also exhibited significant proangiogenic response in chorioallantoic membrane (CAM) assay in addition to the enhanced cell migration. This is the first report of the occurrence of the compounds  1 ,  2 ,  4  and  5  in this plant.

natural product research

In-vitro  cell migration enhancing and pro-angiogenic active secondary metabolites from  Jeffreycia zeylanica  (L.) H. Rob., S.C. Keeley &amp; Skvarla (Asteraceae)