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Alkylamides are secondary metabolites in  Acmella oleracea  and display wide applications in treating several diseases. Since alkylamides can inhibit pain, this work aims to evaluate the antinociceptive profile of  A. Oleracea  methanolic extracts used  in vivo  and  in silico  assays. The extracts inhibited the neurogenic and inflammatory phases of the formalin test, ratifying the antinociceptive effect of alkylamides. Furthermore, the results from molecular docking demonstrated the interaction of  A. oleracea  alkylamides with the CB1/CB2 and TRPV1 receptors. Additionally, the crude methanolic extract of flowers did not induce potential side effects related to the classical cannabinoid tetrad: hypolocomotion and catalepsy. In conclusion, this work confirms the potential of the alkylamides of  A. Oleracea  as antinociceptive agents and, for the first time, correlates its effects with the endocannabinoid and vanilloid systems through  in silico  assays.

Alkylamides from Acmella oleracea : antinociceptive effect and molecular docking with cannabinoid and TRPV1 receptors