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A chemical investigation of  Solanum lyratum  Thumb. (Solanace) afforded two new lignans ( 1b  and  3 ) and eleven known lignan analogues ( 1a ,  2a / 2b  and  4 – 11 ). Compounds  1a / 1b  and  2a / 2b  were separated as two pairs of enantiomers by chiral high-performance liquid chromatography (HPLC). Their structures were elucidated by detailed spectroscopic and comparative literature data analysis. The absolute configurations of compounds  1a / 1b  and  2a / 2b  were determined by comparing the experimental ECD data with the calculated values. All compounds were evaluated for their acetylcholinesterase (AChE) inhibitory activity. Notably, compared to the positive control, compounds  4  and  9  showed obvious AChE inhibition with their IC 50  values of 1.30 ± 0.25 and 0.89 ± 0.04 μM, respectively. In addition, the possible interaction between acetylcholinesterase and the active compounds was also investigated by molecular docking.

Structurally diverse lignans from Solanum lyratum : chemical evidence for their acetylcholinease inhibitory activity