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The rhizome tuber of  Sauromatum giganteum  is known as 'Bai Fuzi’ in China and has been ethnomedicinally used to treat various neurological diseases. It is considered to possess anti-Parkinson’s disease (PD) potential, but the active compounds responsible for that is still unclear. In this work, nineteen compounds were isolated and identified from rhizome tuber of this plant, among which four were firstly reported, i.e. berberine ( 1 ), nicotinamide  (2 ), rutin ( 3 ) and 5-caffeoylquinic acid ( 4 ). Six compounds ( 1 ,  3 ,  4 ,  8 ,  14  and  15 ) exhibited moderate inhibitory activity against MAO-B with IC 50  of 118.8, 45.6, 96.2, 65.8, 40.0, and 49.8  µ M, and two compounds ( 3  and  4 ) displayed significant protective effect on 6-OHDA-induced PC-12 cell model. The molecular docking of the bioactive compounds and MAO-B was carried out to explore the binding mode. The findings revealed the potential of  S. giganteum  as anti-PD herb and its inclusion in TCM could be explored.

Chemical components and monoamine oxidase B inhibition activities from the tubers of Sauromatum giganteum (Engl.) Cusimano & Hett