English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A new sesquiterpene, 1-carbonyl-2,8-dihydroxy-11-oxabicyclo [4,4,1] germacra- 2(3),4(5),6(7),8(9)-tetraene ( 1 ) and four known compounds (3 E , 23 E )-3-caffeoyl-23-coumaroylhederagenin ( 2 ), (3 E , 23 E )-dicoumaroylhederagenin ( 3 ), morettinone ( 4 ), 24-ehylcholesta-3,6-dione ( 5 ) were isolated from the ethyl acetate layer of the fibrous root of  Alangium chinense  (Lour.) Harms. The structure of compound  1  was characterized by its  1 H-NMR,  13 C-NMR, DEPT, HMBC, HSQC spectrums, and the structures of the known compounds were determined by comparison of their spectroscopic data with those reported by the literatures. The obtained compounds were evaluated for their anti-inflammatory against cyclooxygenase (COX-2). Compound  1  has a good inhibitory effect against COX-2 with IC 50  20.43 ± 4.72 μM. The compounds  2 – 5  have inhibitory effect against COX-2 with IC 50  49.19 ± 0.76, 23.29 ± 0.99, 47.78 ± 1.33, and 44.44 ± 0.12 μM, respectively.

Terpenoids as anti-inflammatory substances inhibiting COX-2 isolated from the fibrous roots of Alangium chinense (Lour.) Harms