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An endophytic fungus  Trichoderma citrinoviride  capable of producing active substances was isolated from the arils of  Torreya grandis . Seven compounds were separated from the ethyl acetate extract of fermentation broth and mycelium by chromatography, respectively identified as trichomerol ( 1 ), bisorbicillinolide ( 2 ), sohirnone A ( 3 ), emodin ( 4 ), stigmasterol ( 5 ), ergosterol ( 6 ), daidzein ( 7 ). This study is the first to report of the isolation of the endophytic fungus  T. citrinoviride  from the arils of  T. grandis  with complete assignments of  1 - 7 . Compound  1  and  2  exhibited significant antioxidant activity of diphenyl picryl hydrazinyl with IC 50  38.92 and 3.91 µg/mL, respectively. Compound  1 ,  2 ,  4  and  7  significantly inhibited the growth of  Staphylococcus aureus  with MIC 0.78; 0.39; 0.20 and 0.20 mg/mL, respectively. Current study indicated the presence of endophytic fungus in the arils of  Torreya grandis  that could be responsible for the bioactive metabolite synthesis.

Investigation on bioactive metabolites produced by an endophytic fungus Trichoderma citrinoviride from the arils of Torreya grandis