English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This study demonstrates  in vivo  analgesic and anti-inflammatory properties of hydroalcoholic extracts of leaves, bark and flowers from the  Handroanthus impetiginosus  (Bignoniaceae) plant, recognized as ‘Ipê roxo’ in Brazil. The extracts were evaluated in male Swiss albino mice via oral administration. Moreover, results of the  in vivo  paw oedema test induced by carrageenan revealed that extracts of leaves and bark displayed relevant anti-inflammatory activity potential at the dosage of 100 mg/kg, 300 mg/kg, and 500 mg/kg. Likewise, the results obtained for leaves and flowers extracts suggested potent analgesic action in the conventional hot plate test. UPLC/MS analysis of the hydroalcoholic extracts samples identified metabolites belonging to several classes, mainly naphthoquinones and iridoids derivatives as well as flavonoids. Thus, the obtained results indicate that the extracts of  H. impetiginosus  plant parts could be considered as a complementary herbal medicine for the treatment of pain and inflammation disorders.

natural product research

In vivo  evaluation of analgesic and anti-inflammatory activity of hydroalcoholic extracts from  Handroanthus impetiginosus  and their chemical composition by UPLC/MS analysis