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Herpes simplex virus 1 is one of the most prevalent pathogens worldwide. Resistant strains to current anti-viral treatment have been reported, requiring the search for novel anti-virals. Using a qPCR method to assess anti-herpetic activity from natural products, we analyzed 72 plant extracts from El Salvador and identified eighteen methanolic extracts with anti-viral activity of ≥ 75%. Anti-herpetic activity has not been previously reported in fourteen of the plants ( Euphorbia lancifolia ,  Piper tuberculatum ,  Cordia alliodora ,  Tecoma stans ,  Taraxacum officinale ,  Hamelia patens ,  Witheringia solanacea ,  Emilia fosbergii ,  Gnaphalium viscosum ,  Citrus aurantium ,  Ambrosia peruviana ,  Carica papaya ,  Solanum hazenii andMelothria pendula ). Four extracts were from species with previously reported anti-herpetic activity ( Plantago major ,  Psidium guajava ,  Sida acuta andBursera simaruba ). These extracts effective anti-viral concentrations (EC 50 ) were between 203 and 6.31 µg/mL, while the selectivity indexes (SI) were between 55.91 and 2.57.  Euphorbia lancifolia  showed the most effective anti-viral activity (EC 50  = 6.31 µg/mL, SI = 51.82).

Screening of medicinal plants from El Salvador for anti-viral activity against Herpes simplex 1