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Five compounds  1-5  were reported from leaves and roots of  Cadia purpurea  herein. 2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-17-(1-hydroxypent-4-en-2-yl)-10,13-dimethyl-1H-cyclopenta[a]phenanthren-3-ol ( 1 ), apigenin-7- O -rhaminoglucoside ( 2 ) and 13- O -pyrrolecarboxyl lupanine ( 3 ) were isolated from chloroform and methanol leaves extracts. And 5-((trihydro-2-oxy-4-(hydroxymethyl)-5-(3-hydroxyphenyl)furan-3yl)methyl)benzene-1,2,3,4-tetraol ( 4 ) and bis(2-hydroxybutyl) phthalate ( 5 ) were isolated from the chloroform: methanol (1:1) roots extract. The structures of the compounds were characterized using NMR, IR and GC/MS spectroscopic data.  In vitro  antibacterial and antioxidant activities of leaves extracts and compounds  1 ,  2 ,  4 , and  5  were also evaluated. The present findings disclosed that tested compound isolates and extracts showed dose-dependent antibacterial and antioxidant activities. The molecular docking result indicates that isolated compounds show no violation of the Lipinski’s rule of five. Compounds  1 ,  2 ,  4 , and  5  were reported herein for the first time from the leaves and roots of  C. purpurea . Further biochemical investigation on whole parts of the plant may uncover additional chemical entities with better biological activities.

Compounds with antibacterial and antioxidant activities from Cadia purpurea