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Investigation of the leaves of  Bauhinia thonningii  Schum led to the isolation and identification of a new flavonol derivative, 6-C-methylquercetin-3,4'-dimethyl ether ( 1 ) together with eleven known compounds ( 2 – 13 ), with two of them ( 10  and  11 ) obtained as a mixture. Their structures were established by extensive spectroscopic analyses. Antibacterial activity of compound  1  as well as the reference antibiotic, ciprofloxacin was tested on Gram-negative multidrug-resistant bacteria overexpressing active efflux pumps, and against methicillin-resistant strains of  Staphylococcus aureus  (MRSA). Samples were tested alone and in combination with an efflux pump inhibitor (EPI), phenylalanine-arginine- β -naphthylamide (PAßN). Results show that when compound  1  was tested alone, its inhibitory effects were obtained on 7/10 tested bacteria with the highest MIC value of 128 µg/mL whilst in the presence of EPI, this activity significantly increase in all the 10 bacteria. An interesting antibacterial activity was obtained with compound  1  against  Klebsiella pneumoniae  ATCC11296 (MIC of 4 µg/mL), KP55 and  Staphylococcus aureus  MRSA6 in the presence of the PaßN.

A new flavonol derivative and other compounds from the leaves of Bauhinia thonningii Schum with activity against multidrug-resistant bacteria