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Tuberculosis is a highly infectious ailment worldwide. The emergence of multi-drug resistance and serious adverse effects of anti-TB drugs have led to the continuous search of natural candidates. This study aimed to analyse the chemical profile of  Vitex pinnata  (VP) bark lipophilic extract using GC-MS also evaluating its anti-TB and cytotoxic activities. GC-MS revealed a total of 81 compounds which representing 86% identified compounds.  In vitro  anti-TB of VP lipophilic extract was evaluated using the Microplate Alamar Blue Assay which exhibited MIC value of 62.5 µg/mL.  In vitro  cytotoxicity was evaluated using Water Soluble formazan assay recording IC 50  &gt; 100 and 200 µg/mL using Vero and A-549 cell lines, respectively.  In silico  docking study was performed on the major identified compounds,  n -nonane showed the most favourable binding affinity (ΔG) equals to −33.34 Kcal/mol. The results obtained herein unravelled the potential use of VP  n -hexane extract as a natural anti-TB.

GC-MS profiling of Vitex pinnata bark lipophilic extract and screening of its anti-TB and cytotoxic activities