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This study was conducted with the aim of exploring the molecular and cellular mechanisms of action of the chrysin (natural flavonoid compound) on bladder tumour cell lines with different status of  TP53  (RT4, 5637 and T24). The cells were treated with different concentrations of chrysin (20, 40, 60, 80 and 100 µM) to analyze the cell viability, nuclear division index, mutagenicity, apoptosis rates and expression of genes related to epigenetic events ( DNMT1 ,  HAT1  and  HDAC1 ). Results showed that the treatment with chrysin reduced the cell viability and caused apoptosis, regardless  TP53 . Moreover, in the  TP53 -mutated cell lines, chrysin modulated the expression of the  DNMT1 ,  HAT1  and  HDAC1  epigenetic genes, which might be a plus to the death observed in the cells with p53 mutation.

Chrysin inhibits the cell viability, induces apoptosis and modulates expression of genes related to epigenetic events in bladder cancer cells