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Three new α-glucosidase inhibitory benzo-isochromenes were isolated from the chloroform fraction of  Datura stramonium . Their structures were established with the help of modern spectroscopic techniques and were assigned the names as 1,6,8-triimethoxy-2-methyl-3,4-dihydrobenzoisochromene-5,10-diol, 3,6-dimethoxy-5-hydroxy-4-methylbenzoisochromene-9,11-dione and demethylflavasperon for compounds  1 - 3  respectively. The α-glucosidase inhibiting activity of compound  2  showed strong inhibition with an IC 50  value of 27.5 µM, while compound  1  exhibited moderate activity with IC 50  value of 60.2 µM compared to positive control (acarbose).

Three new α-glucosidase inhibitor benzo-isochromenes from Datura stramonium