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Coriolopsis rigida  was isolated as an endophytic fungus from the medicinal plant  Cochlospermum regium , and their production of secondary metabolites has not yet been investigated. Thus, the endophyte was cultivated on rice solid media to evaluate its ability to produce bioactive compounds and then the chloroform extract was obtained. Two phenolic compounds, tyrosol ( 1 ) and a new natural product  p -hydroxyphenylacetamide ( 2 ), were isolated from the extract. The structures of the compounds were elucidated mainly by NMR. The extract showed potent antioxidant activity with an efficient concentration (EC 50 ) value of 0.33 mg mL −1 . Additionally, demonstrated allelopathic activity inhibited the seedling growth of  Lactuca sativa  L. and  Raphanus sativus  L. by 63% and 55%, respectively.

Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida