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The phytochemical study on the stems and leaves of  Morinda citrifolia  L. resulted in the isolation of a new naturally occurring bisabolane-type sesquiterpenoid, morincitrinoid A ( 1 ), together with five known analogues ( 2 – 6 ). The chemical structure of  1  was elucidated by comprehensive spectral analyses. The known compounds  2 – 6  were identified by comparing their spectral data with those reported in the literature, which were isolated from  M. citrifolia  for the first time. In addition, the anti-inflammatory and anti-HIV activities of compounds  1 – 6  were evaluated  in vitro . Compounds  1 – 6  displayed significant inhibitory activities on NO (nitric oxide) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells with IC 50  values ranging from 0.98 ± 0.07 to 6.32 ± 0.11 μM, which was comparable to hydrocortisone. Meanwhile, compounds  1 – 6  showed remarkable anti-HIV-1 reverse transcriptase (RT) effects with the EC 50  values ranging from 0.16 to 6.29 μM.

Bisabolane-type sesquiterpenoids with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Morinda citrifolia