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Callicarpa kwangtungensis (C. Kw), C. macrophylla (C. Ma), C. nudiflora (C. Nu), C. formosana (C. Fo),  and  C. kochiana (C. Ko)  were medicinal plant resource in China. In this study, the UPLC/Q-TOF-MS analysis was performed and 151 compounds were identified. PCA analysis metabolic profiles of  C. Nu, C. Ko  and  C. Kw  leaves differ significantly from the other two  Callicarpa  species, while  C. Fo  and  C. Ma  share similar chemical constituents. OPLS-DA highlight with an S-plot indicated that there are 14 robust known chemical markers enabling the differentiation between these five  Callicarpa  plants.  C. Ma, C. Nu, and C. Fo  leaves extracts treatment effectively reversed the body weight loss, uric acid and creatinine content, hepatic XOD activity, kidney, liver, and ankle tissues injury and inflammation induced by potassium oxonate in hyperuricemia mice. While  Ko and C. Kw  leaves extracts treatment showed less improvement in hyperuricemia mice.

natural product research

Systematic characterisation of the effective components of five  Callicarpa  species with UPLC-Q-TOF-MS and evaluation of their anti-hyperuricaemic activity