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Metabolites of the fungus  Cunninghamella echinulata  NRRL 1382 were investigated under the effect of fusidic acid ( 1 ) feeding. In addition to ergosterol ( 2 ) which is a fungal sterol, two novel adipate esters ( 3, 4 ) were isolated, and their structures were fully investigated using various spectroscopic analyses, including 1 D, 2 D NMR and HRESIMS.  In silico  biological target prediction and molecular docking investigation revealed a potential agonist/antagonist activity for compound  3  by binding to µ opioid receptor and antidiabetic effect by aldose reductase inhibitory activity for compound  4 .

natural product research

New adipate esters from  Cunninghamella echinulata : isolation, identification, biosynthesis and  in silico  prediction of potential opioid/anti-opioid and antidiabetic activities