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(±)-Patulinervones A ( 1 ) and B ( 2 ), two diastereomers of  spiro -lignans sharing an unprecedented dimethyl- spiro [furan-2,2′-furo[2,3- b ]furan] 5/5/5 tricyclic moiety were isolated from the leaves of  Melicope patulinervia  (Merr. &amp; Chun) C.C. Huang. Their structures were established by extensive spectroscopic data and electronic circular dichroism (ECD) analyses. The racemates (±)- 1  and  2  and their enantiomers exhibited  α -glucosidase inhibitory effect with IC 50  values range of 10.08 ± 1.24 − 25.58 ± 1.97 µM.

Patulinervones A and B, two novel α -glucosidase inhibitory spiro -lignans from Melicope patulinervia (Merr. & Chun) C.C. Huang