English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The disclosed study reveals isolation, characterization and anticancer evaluation of  Rumex dentatus . The extracts and isolated compounds were used for cytotoxic activity against (lung (A549), pancreatic (MIAPaCa), colon (HCT-116), breast (MDA-MB-231) and breast (MDA-MB-468) cell lines. The extracts were screened for cytotoxicity using MTT colorimetric assay. Out of all extracts, methanolic (30) %: chloroform fraction (TAW6) with 75.01% inhibition at a concentration 100 µg/mL was observed. The selected extracts were further processed for column chromatography and led to isolation of seven compounds (A to G). The structural determination of isolated compounds was carried out using  1 HNMR,  13 CNMR, IR and HRMS. All the isolates were tested for cytotoxic activity and compound B was found most active with IC 50  values 11.29 µg against HCT-116 (Colon). The compound B was then used for detailed study via  transwell invasion assay  and  wound healing assay . Thus the significant anticancer activity particularly against colon cancerous cell lines recommends that the ( Rumex dentatus)  could act as a potential drug candidate for cancer, more particularly for colon cancer.

natural product research

Isolation and characterisation of pharmaceutically versatile molecules from  Rumex dentatus  and evaluation of their cytotoxic activity against human cancer cell lines