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Traditional herbal medicinal products (THMP) with  Thymi herba  are very popular as OTC among the European population. The aim of this article was the toxicological risk assessment (TRA) of Cd impurities in THMP with  Thymi herba  from Polish pharmacies. The estimations of Cd impurities in the single dose (1.10–12.90 µg/single dose) and in the daily dose (ng/day) were based on the worst-case scenario (WC), i.e. based on the dosage indicated in the community herbal monograph on  Thymus vulgaris  L. and  Thymus zygis  L., herba by the European Medicines Agency (EMA). The estimated daily exposure (ng/day) meets the standards of the ICH Q3D (R1) guideline (5.0 µg/day) according to the Cd levels (all results were below 40 ng/day). It can be concluded that all THMPs analysed with  Thymi herba  from Polish pharmacies should not represent any health risk to the human health.

natural product research

Cadmium impurities in traditional herbal medicinal products with  Thymi herba  available in Polish pharmacies – short communication: the level of Cd impurities and comprehensive toxicological risk assessment