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Chemical analysis of the methanol extract of the root bark of  Millettia aboensis  led to the isolation of homopterocarpin ( 1 ), secundiflorol I ( 2 ), and maackain ( 3 ). The structures of these compounds were elucidated based on their MS and NMR spectra. The crude methanol root extract was screened for its cytotoxic activity on mouse lymphoma cell line (L5178Y), and the isolated compounds were tested for their antioxidant activity using a 2, 2-diphenylhydrazyl (DPPH) radical scavenging model. The crude methanol root extract gave a percentage growth inhibition of 87.5% on the mouse lymphoma cell line (L5178Y). Compound 3 gave the highest antioxidant activity with an IC 50  of 83   µg/ml. These compounds can serve as leads for anticancer agents.

Cytotoxic effect and antioxidant activity of pterocarpans from Millettia aboensis root