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Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that  Prosthechea karwinskii  leaves extract induces both an  in vitro  antioxidative action and an  in vivo  gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by  Prosthechea karwinskii  are not known. Thus, the aim of this study is to determine whether  Prosthechea karwinskii  extract modifies anti-inflammatory and antioxidative biomarkers in an  in vivo rat  model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and  Prosthechea karwinskii  leaf extract. Our results suggest that the gastroprotective effect of  Prosthechea karwinskii  leaf extract is related to the reduction in leukocyte infiltration and antioxidative action in a model of indomethacin-induced gastric injury. Further studies are warranted to investigate the role of the compounds identified in the gastroprotective action of  Prosthechea karwinskii  leaves extract.

natural product research

Role of LTB4 and nitric oxide in the gastroprotective effect of  Prosthechea karwinskii  leaves extract in the indomethacin-induced gastric injury in the rat