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Phytochemical investigation of the seeds of  Coix lacryma-jobi  var. lacryma-jobi resulted in the isolation of eight compounds, including two new structures, coixdines A-B ( 1-2 ) and six known compounds ( 3-8 ). The structures of these compounds were determined by 1 D and 2 D NMR spectra referring to the literatures, together with HR-MS analysis. Coixdine A and B are first examples of spermidine skeleton in genus  Coix . In the present paper, all compounds were evaluated for the cytotoxicity against two cancer cell lines (CT-26 and BxPC-3)  in vitro , and none of the compounds exhibited obvious cytotoxic activity. The present investigation suggests that these amides seem to be of great chemotaxonomic value for  C. lacryma-jobi .

Two new amides from the seeds of Coix lacryma-jobi var. lacryma-jobi