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Intertidal triangular sea bell  Turbinaria decurrens  (Bory de Saint-Vincent) (family Sargassaceae) belongs to one of the largely abundant genus of marine brown alga. Bioactivity-directed chromatographic purification of the organic extract of  T. decurrens  afforded two new nor-dammarane triterpenoids named as decurrencyclic A-B. Decurrencyclic B showed superior attenuation properties against cyclooxygenase-2 (IC 50  13.98 μM) and 5-lipoxygenase (IC 50  3.02 μM) in contrast with decurrencyclic A. Decurrencyclic B showed higher inhibition potential against COX-2 than that revealed by the anti-inflammatory agent, ibuprofen (IC 50  70.44 μM). The higher selectivity index of decurrencyclics (1.39–1.57) acknowledged their selective attenuation property against inducible cyclooxygenase-2.  In-silico  molecular modeling analysis of decurrencyclic B with the inflammatory enzymes showed least binding energy of −14.55 kcal mol −1 . These reports have proven that decurrencyclic B could be a potential therapeutic lead for use against inflammatory pathogenesis.

Anti-inflammatory decurrencyclics A-B, two undescribed nor-dammarane triterpenes from triangular sea bell Turbinaria decurrens