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In this contribution, ethanolic extracts of  Cuminum cyminum  ( C. cyminum ) seeds were evaluated in terms of phytochemical content, total phenol and flavonoid contents. As far as the analytical techniques are concerned, UV–Vis, FTIR, HPLC, NMR (1H and  13 C) and ESI-MS were performed. The binding capacity of five different antidiabetic enzymes was tested by  in silico  molecular docking studies. The HPLC, UV–Vis, FTIR, NMR and ESI-MS data highlighted the presence of seven biologically active molecules e.g. α-pinene, β-pinene, Δ 3 -carene, ρ-cymene, α-terpineol, cuminaldehyde and linalool. The results coming from the  in silico  molecular docking studies showed that such phytochemicals present in the cumin seed extracts play an important role in the activity of key enzymes involved in carbohydrate metabolism. Therefore,  C. cyminum  is proven to be useful for the treatment of diabetes mellitus and its major secondary complications.

natural product research

Phytochemical screening of ethanolic extracts of  Cuminum cyminum  L. seeds along with the evaluation of antidiabetic properties by molecular docking approach