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Antrodia camphorata  is used as a medicinal fungus in Taiwan to treat fatigue, food intoxication, and enhance liver function. Here we identified fermented metabolic components from the mycelium of  A. camphorata  KH37 and explored their anti-hepatoma potentials with study models of human hepatoblastoma cell lines. Bioassay-guided fractionation of the solid fermentation powder of  A. camphorata  KH37 led to the isolation of one new quinonol, antroquinonol Z ( 1 ), and nine known compounds ( 2 – 10 ). Treatment with 10 μM antrocamols LT1 ( 2 ) or LT3 ( 3 ) reduced cell viability of HepG2 and Huh-7 cells to about 60% in 48 hours. Antroquinonol Z ( 1 ) exhibited mild cytotoxicity against Huh-7 cells in 48 and 72 hours. Interestingly, two fractions showed cytotoxicity in HepG2 and Huh-7 cells, even better than compounds isolated from these fractions. The significant cytotoxicity of partially purified samples from  A. camphorata  KH37 exhibited a potential for developing alternative or complementary therapeutics against hepatoma.

Chemical investigations and cytotoxic effects of metabolites from Antrodia camphorata against human hepatocellular carcinoma cells