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In this work, a total of 19 novel naphthalene hybrids with chimonanthine scaffolds were efficiently synthesised from indole-3-acetonitrile in good yields. The prepared compounds were evaluated for biological activity against  Cryptococcus neoformans, Escherichia coli, Shigella spp, Candida albicans, Salmonella spp,  and  Staphylococcus aureus . The preliminary bioassays showed that most of the synthesised compounds exhibited significant antibacterial or antifungal activity. Notably, compound  8  showed potent activity against  Cryptococcus neofonmans ,  Escherichia coli ,  Shigella spp , and  Candida albicans  than the positive control, all with the same MIC value of 3.53 µM. Compound  8  had a broad spectrum of antibacterial or antifungal activity, and will be studied further.

Synthesis of novel naphthalene-chimonanthine scaffolds hybrids with potent antibacterial or antifungal activity