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Chemical investigation of the MeOH extract of the leaves of  Scyphocephalium mannii  (Benth. &amp; Hook.f.) Warb. (Myristicaceae) led to the isolation and characterization of one new metabolite ( + )-(7’ S , 8 S , 8’ S )-4,4’-dihydroxy-3,3’,5,5’-tetramethoxy-2,7’-cyclolignan ( 1 ) along with five known compounds. Their structures were elucidated by spectroscopic means, including 1 D and 2 D NMR, HRESI-MS and by comparison with published data. The absolute configuration of compound  1  was determined by single-crystal X-RAY diffraction. Compound  1  showed moderate antifungal activity against  Cryptococcus neoformans  with respective MIC and MMC values of 64 and 256 µg/mL.

New antimicrobial cyclolignan and others constituents from the leaves of Scyphocephalium mannii (Benth. & Hook.f.) Warb