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Two new sorbicillinoid derivatives ( 1  and  2 ), together with ten other related compounds ( 3–12 ) were isolated from a Hawaiian marine fungal strain  Trichoderma  sp. FM652. The structures of compounds  1  and  2 , including the absolute configuration, were elucidated by extensive analysis of NMR spectroscopy, HRESIMS and electronic circular dichroism (ECD) data. Compounds  6–12  exhibited significant anti-proliferative activity against ovarian cancer cell line A2780, with the IC 50  values ranging from 0.5 to 8.07 μM. Moreover, compounds  1 ,  7  and  8  showed significant inhibition against NF-κB with IC 50  values of 13.83, 24.40 and 14.63 µM, respectively. Compounds  6 ,  9  and  12  also demonstrated moderate inhibitory activity against  S. aureus  and methicillin resistant  S. aureus  with the MIC values in the range of 10–40 μg/mL.

New and bioactive polyketides from Hawaiian marine-derived fungus Trichoderma sp. FM652