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In this study, 13 new hybrid compounds  (7a-m)  were synthesised starting from ursolic acid, and their cytotoxic activities were investigated on the BEAS-2B and A549 cell lines. In addition, the synthesised compounds were tested against  Staphylococcus aureus ,  Escherichia coli , and  Candida albicans  to determine their anti-microbial properties. The hybrid compounds that exhibited the lowest cytotoxicity against the BEAS-2B were  7k, 7b,  and  7g . The cytotoxicity of the compounds against A549 was evaluated, the IC 50  value of  7k ,  7b,  and  7g  are found as 0.15 µM, 0.31 µM, and 0.26 µM, respectively. The results showed that the selectivity of  7k  was 7 times higher than doxorubicin against the A549 cells. According to the antimicrobial activity studies  7c  is found as the most effective compound against  S. aureus.  Almost all compounds showed a similar inhibition potential against  E. coli and C. albicans.

Synthesis of ursolic acid arylidene-hydrazide hybrid compounds and investigation of their cytotoxic and antimicrobial effects