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A novel tyroscherin derivative named pseudallecin A ( 1 ) with a natural unprecedented morpholine-2, 3-dione structural unit, and a new biogenic synthesis related organic acid named pseudallecin B ( 2 ) were purified from a symbiotic fungus  Pseudallescheria boydii  derived from  Pomacea canaliculata . Their structures were elucidated via spectroscopic analyses and ECD calculation. Pseudallecin A exhibited strong inhibitory activities against both Gram-positive  Escherichia coli  and Gram-negative  Staphylococcus aureus .

natural product research

A novel antibacterial tyroscherin derivative with a natural unprecedented morpholine-2, 3-dione structural unit from the fungus  Pseudallescheria boydii