English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The phytochemical investigation of the DCM/MeOH (1:1) extract of the fruits of  Cnestis ferruginea  led to the isolation and characterization of one new quinic acid derivative, ferruginoic acid ( 1 ), together with six known compounds  2–7 . Compounds  3–7  were reported for the first time from this species. The structures of compounds  1 – 7  were elucidated on the basis of 1 D and 2 D NMR spectroscopic data, mass spectrometry and by comparison of spectroscopic data with those from the literature. The anticholinesterase (AChE and BChE) activity and DPPH free radical scavenging assay of compounds  1 ,  3 ,  4  and  7  were evaluated. Ferruginoic acid ( 1 ) exhibited moderate anticholinesterase activity with IC 50  value of 36.18 ± 1.78 µg/mL against AChE. Compounds  3, 4  and  7  showed high activity against free radical (DPPH • ) scavenging assay (DPPH) with IC 50  values 40.09 ± 0.96 µg/mL, 61.70 ± 0.78 µg/mL and 41.87 ± 0.62 µg/mL respectively. These results indicate that  C. ferruginea  and its constituents could be employed in the management of Alzheimer’s disease.

natural product research

Chemical constituents from fruits of  Cnestis ferruginea  Vahl ex. DC (Connaraceae) and evaluation of their anticholinesterase and antiradical activities