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Starting from L-tryptophan, 19 new  N -substituted chiral indole analogs were synthesized. The prepared compounds were evaluated for biological activity against  Sclerotinia sclerotiorum ,  Alternaria solani ,  Verticillium dahliae ,  Colletotrichum orbiculare ,  Cytospora juglandis  and  Curvularia lunata . The preliminary bioassays showed that most of the synthesized compounds exhibited fungicidal activity. Compound  b13  in particular exhibited significant antifungal activity against  Verticillium dahliae  and  Sclerotinia sclerotiorum , with the MIC value of 1.95 µg mL −1 . Compound  b13  also showed excellent activity against six plant pathogen fungi, and was identified as the most active on the biological assays, and will be studied further.

Synthesis and antifungal activity of novel chiral indole analogues