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A new  C -benzylated flavone, uvariaruflavone ( 1 ), along with 13 known compounds ( 2 – 14 ) were isolated from the twig and leaf extracts of  Uvaria rufa  Blume. Their structures were established by extensive spectroscopic methods. Flavones ( 5 – 8 ) and cyclohexene ( 10 ) were isolated from  U. rufa  for the first time. Most of the isolated compounds were evaluated for their  α -glucosidase and  α -amylase inhibitory activities. Of these, uvariaruflavone ( 1 ) showed the highest  α -glucosidase inhibitory activity with an IC 50  value of 44.3 µM, while ferrudiol ( 12 ) displayed the highest  α -amylase inhibitory activity with an IC 50  value of 73.5 µM.

α -Glucosidase inhibitory and α -amylase inhibitory activities of compounds isolated from Uvaria rufa Blume