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Herein, we reported a systematic scientific study of  Arenga westerhoutii  Griff. by evaluating its bioactive components, nutraceuticals, antioxidant and anti-diabetic properties. Three major bioactive compounds were identified using HPLC and HRMS. Quantification of the components through HPLC yielded the presence of 75.67 ± 0.05, 38.19 ± 0.10 and 13.11 ± 0.02 µg/mL of chlorogenic acid, ferulic acid and epicatechin respectively in 1 mg/ml of the extract. 50% MeOH hydro-alcoholic extract was found to show lowest IC 50  value in both  in-vitro  antioxidant (IC 50  = 2.925 ± 0.12 µg/mL, DPPH assay) and anti-diabetic assays (IC 50  = 18.03 ± 0.18 µg/mL, α-glucosidase assay). Further analysis by molecular docking study suggested the interaction of components towards α-glucosidase enzyme.

natural product research

Arenga westerhoutii  Griff.: bioactive constituents, nutraceuticals, antioxidant and anti-diabetic potential of stem extract and an insight into molecular docking analysis