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Aims of the study were the phytochemical investigation and chemical transformation of isolated compounds of medicinal plant listed in ‘Ayurveda’ like  Dolichandrone atrovirens , endemic to Indian subcontinents. From chloroform extract of  D. atrovirens  four compounds; Ursolic acid ( 1 ), Maslinic acid ( 2 ), Lupeol ( 3 ),  β -sitosterol ( 4 ) and from methanol extract five compounds;  β -sitosterol-3- O - β -D-glucopyranoside ( 5 ), 10- O - trans - p -Methoxycinnamoylcatalpol ( 6 ), Kaempferol-3- O - β -D-glucopyranoside ( 7 ), 6- O -[6"( S )-hydroxy-2",6"dimethyl-2"(E)-7"-octadienoyl] catalpol ( 8 ) and Ixoside ( 9 ) were isolated. Ixoside was used for the semi-synthetic modification via azomethine ylide cycloaddition leading to novel spiro-oxindolo-pyrrolizidine adduct. The structures of novel adducts were elucidated by analysis of IR, MS and 1 D/2D NMR data. Furthermore, to confirm the chemo selection of only one double bond, we performed density functional theory (DFT) calculation, which confirms the chemo selectivity. In addition,  in-silico  ADME studies and atom-additive approach based on SASA was also examined for the molecules which suggest that they may be potential future candidates for drug discovery.

natural product research

Isolation of phytochemicals from  Dolichandrone atrovirens  followed by semisynthetic modification of ixoside via azomethine ylide cycloaddition; computational approach towards chemo-selection