English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Natural antimicrobial products have been historically used for the prevention and control of biofilm-dependent oral diseases. We determined the physicochemical characteristics of  Origanum vulgare  L. essential oil (OEO) and carvacrol (CAR), and their  in vitro  antimicrobial activity against cariogenic bacteria.  In silico  analysis was further carried out to examine the pharmacokinetics of CAR. The antimicrobial activity of OEO and CAR was determined through agar diffusion test, biofilm assays, and the checkboard test. Data were analyzed by Tukey's post hoc test. OEO showed inhibitory activity on bacterial growth, which was enhanced with the addition of CAR and greater than that of CAR alone.  In silico  analysis indicated good theoretical bioavailability of CAR. CAR showed effective physicochemical characteristics as an antimicrobial drug due to its favorable theoretical absorption and distribution kinetics. Collectively, our findings suggest that OEO and CAR warrant further investigations as promising natural products for controlling cariogenic biofilms.

natural product research

Physicochemical characteristics and antimicrobial activity of  Origanum vulgare  L. essential oil and carvacrol on cariogenic bacteria: an  in vitro  and  in silico  study