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The methanolic extracts of  Pterocaulon alopecuroides  and  Pterocaulon angustifolium  were assayed for antibacterial activity and biofilm formation inhibition of four community-acquired-MRSA isolates representative of ST30 t975, ST30 t021, ST5 t311, and ST4335 t008 clones that are responsible for invasive infections in Paraguayan children. Both  Pterocaulon  extracts showed significant antibacterial activity with a minimum inhibitory concentration of 200 µg/mL against the four isolates.  P. angustifolium  showed inhibition of biofilm formation for the four isolates, whereas  P. alopecuroides  showed inhibition for three of them. The chemical constituents were identified by liquid chromatography coupled to tandem mass spectrometry. Phenolic compounds were detected in the two species as well as coumarins. These results showed that these plants are sources of compounds with activity against MRSA.

natural product research

In vitro  antibacterial activity, biofilm formation inhibition and chromatographic profile of methanolic extracts of two  Pterocaulon  species against MRSA